Lipids are fatty acids compounds or their derivatives. Lipids are insoluble in water but soluble in organic solvents. Examples of lipids include fats, oils, waxes, certain vitamins (such as A, D, E and K), hormones and most of the cell membrane that is not made up of protein. Lipid-based drug delivery is one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs.
Lipid nanoparticles (LNPs) have emerged across the biopharmaceutical industry as a delivery vehicle for variety of therapeutic agents including mRNA, siRNA, and ASO’s etc. With recent success of COVID-19 mRNA vaccines (Moderna mRNA-1273 and BioNTech BNT162), LNPs gathered considerable attention for various mRNA-based vaccine developments. All the current FDA-approved LNP formulations contain four lipids an (1) ionizable cationic lipid, helper lipids which include (2) 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and (3) cholesterol, and (4) a polyethylene glycol (PEG)-lipid conjugate. These constituents facilitate monodisperse nanoparticle formation, improve nanoparticle stability, enable efficient nucleic acid encapsulation, aid cellular uptake, and promote endosomal escape of nucleic acid cargo.
Components of lipid nanoparticles.
Glycomindsynth provides offers a wide variety of ionizable lipid standards to our clients worldwide. We are dedicated to custom synthesis of variety of ionizable lipid molecules to support the LNP-based drug delivery efforts.
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